01

EncorePOOL Technology

  • Generate stable bulk pools producing 1-5 g/L for most mAbs in just 2 weeks.
  • Ideal for early developability assessment and material generation.

02

EncoreSTAR Technology

  • Proprietary method enriches high-producing clones before single-cell cloning.
  • Enhances screening efficiency by 10-20 fold.

03

EncoreSELECT Technology

  • Directed evolution approach selects for clones with high productivity and desired phenotypes.
  • Improves growth characteristics and product quality attributes.

04

Quick Turn-a-round

  • Streamlined process delivers DNA bulk pools in ~2 weeks.
  • Top clones available in ~10 weeks.

Our Workflow

1. Construction of the expression vector;

2. Transfection and selection, about 2 weeks;

3, (optional) do protein production with bulk pool cells, for research purpose. if for pharmaceutic production, contrinue with cell sorting;

4, Cell imaging and growing, about 2-3 weeks;

5, 96-well plate clone screening and expansion, about 2-3 weeks;

6, Clone fed-batch evaluation about 2 weeks;

7, select top clones with titer and product quality analysis, about 2 weeks;

8, Pre-Clinic Batch ready;

9, Stability study, Master Cell Bank (MCB) ready.

EncoreSTAR Technology

  • Enrich high producing clones before single cell cloning.
  • Improve clone screening efficiency by 10-20-folds.

EncorePOOL Technology

  • Fast stable bulk pool: ~2 weeks from transfection.
  • High titers: 1-5g/L for most mAb.

 

Applications of EncorePOOL:

  1. Developability assessment: titer, product quality, etc.
  2. Process development: pools can be used for process optimization before clones are available.
  3. Material generation: replace transient expression to provide protein material for candidate screening, developability studies, and animal study.

 

Together We Thrive !

America Diagnostics, 9235 Activity Road, Suite 101, San Diego, CA 92126 USA   Tel: (858) 282-8567  Email: info@ameridx.com

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